https://mphelpslab.org/news-and-ideas daily 0.75 2022-12-17 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/04c735ce-7bac-487c-867a-92ad880c2acb/Image+%285%29.jpeg News and Ideas Invasive species such as this carp compete with salmon for habitat https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1c406758-79f2-4cbc-865e-6eaea6f3c565/Image+%284%29.jpeg News and Ideas Male Chinook salmon sampled for biological data https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/d86b270c-a8fc-452f-8527-9d4933ff8e9c/Image+%283%29.jpeg News and Ideas Female Chinook salmon sampled for biological data https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/7e93cef2-9cd7-402b-8c16-91af1a349f4d/Image+%282%29.jpeg News and Ideas Female Chinook salmon sampled for biological data https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/68daa0a9-f7a0-4c3e-ba0e-fe6e85201854/Image+%281%29.jpeg News and Ideas Female Chinook salmon sampled for biological data https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/b12d3546-000d-46b7-afac-525168e70b86/Image.jpeg News and Ideas Female Chinook salmon sampled for biological data https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598823054644-HFSP3M6VTB7OH4VA576V/20190815_193248.jpg https://mphelpslab.org/news-and-ideas/weawvscalqbmux9d7vzgxr7ibou96h monthly 0.5 2022-12-17 https://mphelpslab.org/news-and-ideas/iof7nfe7gdm1gyi2woxi9vk5gu0ngi monthly 0.5 2022-12-17 https://mphelpslab.org/news-and-ideas/blog-post-title-one-spgp7 monthly 0.5 2022-11-16 https://mphelpslab.org/home daily 1.0 2024-09-10 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1620346965823-W9WQSMDET6FR4W5KY75N/WhatsApp+Image+2020-12-01+at+12.37.41+PM+%281%29.jpeg Home - Team Meet the dedicated scientists https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1620347088802-0HEJZQL2T9XOHVFSIZ9L/slc45a2+Knockout.png Home - Research What questions are we addressing? https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598832259067-1TJC65MAXYSXZKU6JX9J/TCSPG+Logo+v4.jpg Home - Thorgaard Center for Salmonid Physiology and Genomics Salmonid Research at Washington State University https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/a32b0c55-ee0c-4adc-ac60-acc138d9e822/Fisheries+Club.jpg https://mphelpslab.org/research daily 0.75 2022-11-02 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598835380722-VZMIBAVWSSDCO45RILQV/F1+AA26-24+cropped.jpg https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598835542707-XVCOCREAJLSH2KE9D7WW/20200121_183523.jpg https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1620347088802-0HEJZQL2T9XOHVFSIZ9L/slc45a2+Knockout.png https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/4e8a8ed0-ee8d-450d-b54f-d54f395897c8/20200602_143907.jpg https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/12e008a5-e7b7-4b86-af3e-1a2a5e77f81c/inhba3+XX+M+DF2B+-+80%25+ALBINO.jpg https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/9d39301d-5591-4b21-a701-9331f0b818b6/inhba1+XY+M+DEFF.jpg https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/21019bc0-4cc8-4ba0-aea4-93c9449151fe/Decode+the+Salmonid+Genome+v2.png https://mphelpslab.org/resources daily 0.75 2023-02-03 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/3cc71fff-59ea-4b5e-bf33-ace8e8f420bf/Chinook+Crop.jpeg https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/52d004a4-a417-4d98-a65d-ad40a98bafa0/Tad.jpg https://mphelpslab.org/publications daily 0.75 2025-11-19 https://mphelpslab.org/tcspg daily 0.75 2021-06-02 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598834680309-GNWHA1H6F527RHYCMH94/TCSPG+Logo+v4.jpg TCSPG https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598834792276-B8C1JE0IKEAZ11J4XI92/20200602_144340.jpg TCSPG https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598834853838-369E4FMIDMTLY2TAJWCR/IMG_20110731_132522.jpg TCSPG https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598834960037-BTV711BEP5H652IKX259/20200121_183501.jpg TCSPG https://mphelpslab.org/opportunities daily 0.75 2026-01-17 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622683748487-U96D12JCXRJJ20POCQIN/WhatsApp+Image+2020-12-01+at+12.36.23+PM.jpeg Opportunities - Research Opportunities Graduate Researchers We often have research or teaching assistantships available for highly motivated Masters or PhD students. We have a wide variety of research projects and availability of assistantships depends heavily on the availability of research funding. If are interested in our laboratory or have specific project ideas as an undergraduate we can work you to submit graduate fellowship applications through the National Science Foundation or other organizations. ____________________________________________________________________________ Postdoctoral Researcher The laboratory occasionally has positions for postdoctoral researchers and are always interested in working with individuals on postdoctoral fellowship applications for research in our lab. See below for any open postdoctoral opportunities: ____________________________________________________________________________ Undergraduate Researchers Our laboratory hosts many undergraduate students both within and outside of WSU. We have many volunteer research project opportunities for undergraduates to gain research experience so contact our lab for the availability of undergraduate opportunities. The lab is a fast-paced environment so we are only interested in highly motivated, career-driven students that can directly articulate how research experience will benefit their career goals. We also often have opportunities for undergraduates to be involved in paid student hourly positions to help with specific laboratory tasks and fish husbandry/maintenance. Open positions are posted below, contact the lab for more information if you are interested: _____________________________________________________________ https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/a32b0c55-ee0c-4adc-ac60-acc138d9e822/Fisheries+Club.jpg https://mphelpslab.org/organismal-biology daily 0.75 2024-07-26 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622675673374-2JZTSTMZ6PYVKAJF0BWN/IMG_1963.JPG Organismal Biology - Salmonid Skeletal Muscle Growth and Development We are investigating the function of the activin/myostatin signaling pathway in rainbow trout. The activin pathway is an important regulator of many biological processes including skeletal muscle growth, reproduction and embryonic development. The lab is investigating the regulation of the pathway across tissues and muscle developmental stages to identify the genes and gene paralogs that coordinate singling in different tissues. We are also creating gene-edited model systems to study the function of key ligands, receptors, and inhibitors of the pathway. https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622677087604-SG8WE39UYRLF1C8C5J1S/1476330-pinksalmon.jpg%3Bw%3D960.jpg Organismal Biology - Pink Salmon Maturation and Sexual Dimorphism Pink salmon (Oncorhynchus gorbuscha) are unique among salmonid species in that they exhibit tight control of their reproductive maturation, reaching sexual maturity at 2 years of age. They also exhibit remarkable secondary sex characteristic that lead to the remodeling of skeletal muscle tissue to create large humps in males. We are interested in understanding how these physiological processes work by using gene expression profiling and functional studies in both wild and laboratory lines of pink salmon. https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622677147075-8DN02QW9043JCR9X0Y44/Dogfish.jpg Organismal Biology - Pacific Spiny Dogfish Population Assessment Pacific spiny dogfish, Squalus suckleyi, are a widely distributed shark species that are keystone species in temperate marine ecosystems. This sub-species branched away from Squalus acanthias, only a decade ago and there remains to be questions about their population structure and health. We are working with NOAA and WDFW in sample collection to investigate population structure and specific genetic markers that may influence evolutionary pressures for this sub-species. https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622678147105-LWXZEXGU90DG4IY43YIC/Trailblazer21+Figure1.png Organismal Biology - Viral Disease Mechanisms Viruses are arguably the most successful pathogen and have developed a vast array of biological mechanisms. Our lab is using CRISPR genome editing technology to identify the mechanisms by which viruses invade host cells. A major goal of this research is to identify strategies to increase disease resistance or produce novel antiviral therapies in cultured and wild fish. https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622694767149-4WB4MXTJ6C70QNMFYXE9/WhatsApp+Image+2020-12-01+at+12.36.40+PM.jpeg Organismal Biology - Mechanisms of Thermal Tolerance in Chinook Salmon Several salmonid species are threatend by the alarming increase in stream temperatures across their native range. Chinook salmon (Oncorhynchus tshawytscha) are one of the vulnerable species that have profound economic, ecological, and cultural significance. We are using natural warm water adapted populations of Chinook salmon to understand the physiological mechanisms of thermal tolerance in Chinook. Our research seeks to provide insight into how these iconic species may cope with future warming trends to provide fisheries managers with the tools to help preserve populations that are impacted by projected ecosystem changes. https://mphelpslab.org/team daily 0.75 2026-02-24 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1663648514171-A44ZPAKQPH1LNDPTLJ5H/Alex.JPEG Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1663650413267-4J6W4W0XP6LYDN74XELY/Jasmine%2BPhoto.jpg Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1663651241726-F4YZDF44LZYUWBBEMOZS/Shubhankar+Photo.JPG Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/9312942a-fac4-4a90-99a5-8a395ef987ba/PP2.JPG Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/46e3ecb4-ed1b-466b-8337-f5c456abe28a/thumbnail_image003.png Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/95d31ff7-c572-44b8-8a5b-843310190c40/PaulBetsy%281%29.jpg Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/d6e0dd34-5432-4dc2-90ec-a538a1809b50/Sabrina_haney.jpg Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/6d2c4376-798c-4dad-b8db-87351c600798/IMG_2432-preview.jpeg Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/10d0e118-b228-4152-ba94-5d27ada395a7/Brad+Dimos.jpg Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1479cdb5-ed3d-4422-893a-0a948e615f22/Chaya.jpg Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/ec22e212-130e-4386-bb49-6fac94abd2d3/Sekiu+Chinook+Salmon.jpg Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622691226912-19WNPSMT2X0AQZN1ZYNA/Phelps+Headshot2.png Team https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/71f3c7d0-b2d9-43cd-b75d-4d97171057da/ad04786a-7e26-4102-a7aa-5efa970f74d7.jpg Team - Fall Chinook on the Clearwater River, near Lewiston Idaho https://mphelpslab.org/aquaculture daily 0.75 2020-08-31 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598834061297-YFBJTFW82NTIEDH6B7R0/20200602_144558.jpg Aquaculture - Aquaculture https://mphelpslab.org/fisheries-and-conservation daily 0.75 2020-08-31 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598835092695-FKLO16VDS7Z87GN68TZ4/WP_20170904_09_05_50_Pro.jpg Fisheries and Conservation - Fisheries and Conservation https://mphelpslab.org/education daily 0.75 2020-08-31 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1598835278982-MW9D5KS8NL4RJOZNDI72/20190822_184407.jpg Education - Education https://mphelpslab.org/biotechnology daily 0.75 2021-06-03 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622680089259-Y6ML1M9U3NFQF6D8GOSH/Figure+1b.png Biotechnology - Trojan Virus Technology Our laboratory is developing selectively replicating viral vectors that can seek out and destroy viral pathogens. This viral-antiviral technology uses pathogen-derived genome structures to replicate and spread the therapy between infected cells while using CRISPR genome editing technology to target viral pathogens. Trojan virus technology is species independent and therefore can be engineered to combat diverse viral pathogens infecting fish, mammals, and plant species. https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622680148114-4RQ9W6QEK3AZ0771TVTY/Figure+7.png Biotechnology - Fish Gene Therapy Technology Gene therapy technology in mammals has led to important biological discoveries and clinical applications. We are developing fish gene therapy viruses to transfer genetic material to select tissues of fish. The technology will help advance basic fish biology research and to increase genetic engineering capabilities in wild and cultured fish. https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622681054525-V94YYOFYPUMR19Z0LTI8/Albino.jpg Biotechnology - Enhancing Aquaculture Sustainability and Production through Gene Editing The increasing global acceptance for gene-edited agricultural products suggests that CRISPR genome editing technology will revolutionize the aquaculture industry, enabling the production of more sustainable, healthy, and productive fish stocks. Since the development of new gene-edited fish lines for commercial production will take years to develop, we are investing heavily in research and development to solve important challenges facing the salmonid aquaculture industry. https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622681533621-8PIGFFII0D9QJ3IUV02E/20200504_113103+B.jpg Biotechnology - CRISPR Nucleic Acid Detection Technology We are using new CRISPR-based nucleic acid detection technologies to develop rapid tests for disease diagnostics, sexing, and environmental DNA monitoring of salmonid species. The technology shows promise as a field based application that does not require specialized equipment or diagnostic facilities. https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/1622695369605-JCOAKTEYZPNC3G02QPXD/WhatsApp+Image+2020-12-01+at+12.37.35+PM.jpeg Biotechnology - CRISPR Conservation Species conservation is a challenging field that is far too often limited in the tools necessary to conserve threatened species. Our laboratory is developing technologies that could someday be used to slow or reverse species decline. The technologies that we are developing include; CRISPR-based invasive species elimination technologies, genetic barcoding approaches, and environmental DNA-based genetic stock identification. https://mphelpslab.org/pstdocmolbio daily 0.75 2022-01-07 https://mphelpslab.org/fish-manager daily 0.75 2022-01-07 https://mphelpslab.org/decode-the-salmonid-genome daily 0.75 2022-12-18 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/d26d3209-a291-47b5-945c-9e2521065eb6/Decode+the+Salmonid+Genome+Project.png https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/e1def26a-1a9c-4439-840a-a0ec95d8af2e/Fish+Salmonid+Decode+Project.png https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/6a145f5a-d13c-4693-babc-627cae45579e/Unknown+M+DF13+Albino.JPG https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/2d1d67f5-3db6-4fb5-8d00-9a36be362080/Edited+fish+4.jpg https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/58e1936a-f4c8-4ffb-a2cc-91b1527513e4/In+vivo+CRISPR+Screen.jpg https://mphelpslab.org/book-a-room daily 0.75 2022-11-18 https://mphelpslab.org/new-page-1 daily 0.75 2022-11-26 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/0b58b081-16f9-4854-961a-2d673adee221/20220519_085911.jpg https://mphelpslab.org/hope-for-salmon daily 0.75 2023-04-27 https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/5a97e923-4c33-44b1-8f5d-1424c11c282e/Logo+1.png https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/903d4589-7389-4956-b060-a6e74a42e108/Asset+2.png https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/3c4514e1-49a2-4844-9a75-40de89c4529c/Rose_George_pic_CeliloFalls_LonePine_CR%5B25%5D.jpg https://images.squarespace-cdn.com/content/v1/5f4bdb1cd1fbe943c7a0589c/c9553c94-0269-41ed-b308-667be84dc118/Nez+Perce+logo.png https://mphelpslab.org/new-page-3 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